鸡蛋清白蛋白 金标级，99%
R20491
干酪素 精制级，92%，牛奶提取
S80135
产品详情
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产品描述： PP121 is a multi-targeted kinase inhibitor with IC50s of 10, 60, 12, 14, 2 nM for mTOR, DNK-PK, VEGFR2, Src, PDGFR, respectively.
靶点： VEGFR2:12 nM (IC50);PDGFR:2 nM (IC50);mTOR:10 nM (IC50);DNK-PK:60 nM (IC50);Src:14 nM (IC50)
体内研究： Oral administration of PP121 remarkably inhibits Eca-109 xenograft growth. Mice body weights are not significantly affected by PP121 or the vehicle treatment. PP121 oral administration dramatically inhibits activations of Akt-mTOR and NFkB in xenograft tumors. p-Akt Ser 473 and p-IKKa/b are both inhibited by PP121 administration
溶解度： Soluble in DMSO
保存条件： -20℃
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